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doi: 10.3390/ijms25042311 261 GhnenisABOdhiamboJFMcCormickRJNathanielszPWFordSP

This meant that GLP-1RA could not only indirectly mediate M2 polarization of microglia by regulating Tregs, but also directly bind to GLP-1R on the membrane surface of microglia, completing M2 polarization through the GLP-1R/cAMP/PKA/IL-10 signaling pathway ( Recent research showed that GLP-1RA could reduce plasma TNF- levels induced by different Toll-like receptor agonists and significantly inhibit neuroinflammation (98)

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The results indicated significant improvements in subjective and objective sleep measures, including reduced sleep onset latency and wake time after sleep onset, alongside increased total sleep time and sleep efficiency [180]