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In clinical trials, participants using these medications alongside lifestyle modifications demonstrated meaningful weight loss over 68-72 weeks, depending on the medication and dosage

The pattern across the timeline is that tolerability improves as effect accrues the roughest GI window is early, precisely when weight change is smallest, and by the time therapeutic doses are driving measurable change the gut has usually adapted to each step

2021 Clinical practice guidelines for diabetes mellitus of the Korean Diabetes Association

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