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On this point, Rinaman noted: Its not clear whether that is due to receptor desensitization or other compensatory mechanismseither neural, physiological, or behavioral. There is also limited data on how chronic treatment reshapes brain circuits
5,6 DNA damage is also linked to neurodegenerative disorders, with the accumulation of DNA lesions in neurons being associated with Alzheimers, Huntingtons and Parkinsons diseases
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