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[10] Other uncommon adverse effects reported with very high doses include dermatological lesions (photosensitivity and skin rash), gastrointestinal upset, and in some cases dependency syndromes (e.g

loading b12 injections Shots at Home: How, Where & How Often to Inject Yourself B12 - Correct treatment -

The human equivalent dose for the cyano- and methyl-cobalamin drinking water used in these studies is ~5000 g/day (CNCbl10 & MeCbl10) and ~25,000 g/day (CNCbl40 & MeCbl40), which was calculated using the standard human equivalent dose parameters [18]

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Vitamin C in its ascorbic acid form is a notable example

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