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doi: 10.3389/fimmu.2023.1139589 Received 07 January 2023 Accepted 20 March 2023 Published 18 April 2023 Volume 14 - 2023 Edited by Qun Zhao, Fourth Hospital of Hebei Medical University, China Reviewed by Laiping Zhong, Shanghai Jiao Tong University, China

Always in rats, continuous light exposure led to diminished humoral responses and interleukin-2 (IL-2) secretion, as well as persistent disruption of circadian leukocyte rhythms and decreased number and activation of NK cells 90,91

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These peels can be used in conjunction with hydroquinones, kojic acid, and hydrocortisone, to increase the improvement of the PIH

Therefore, the corresponding treatments were T1 with 0 mg/kg, T2 with 150 mg/kg, T3 with 300 mg/kg, T4 with 450 mg/kg, and T5 with 600 mg/kg of AcM