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Inhibiting the LOX enzyme allows loosening of matrix stiffness, fibronectin disruption, and improved drug penetration (111)

Normal immune signaling needed for healing stays intact. KPVs strongest preclinical evidence is for oral delivery to gut tissue, where inflamed cells actively absorb it. Subcutaneous KLOW distributes it systemically instead, which suits skin-local inflammation but has not been tested in controlled human trials for blends like this

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