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This is largely because our stomachs tend to produce less acid as we get older

10.7554/eLife.58737 Elife 4 AngamoE

Why the Findings Do Not Establish Cancer Prevention Mouse strains differ greatly in their background tumour risks

Exenatide also reduced high-sensitivity C-reactive protein by 61% [85] and reduced urinary transforming growth factor- 1 and type IV collagen excretion in patients with T2DM [86]

The prevalence of this deficiency also increases with age (Allen, 2009)