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Dose adjustment: Since the thermogenic effect is dose-dependent, patients on 12mg who find it disruptive may discuss with their physician whether 9mg provides adequate weight loss with a more tolerable thermal profile

The principal target cell types for GLP-1 (islet cells stained with insulin antiserum) and GLP-2 (intestinal endocrine cells stained with GLP-2 receptor antiserum) are shown below the peptide sequences

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Bismuth also directly curbs diarrhea by reducing the amount of liquid secreted by the small intestine and increasing water absorption in the colon, making stools firmer