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However, as the initial novelty of these prescriptions fades, residents are beginning to ask deeper questions about what theyre actually losing when the scale moves down

As a key energy substrate for tumor cells, Gln can be catabolized by glutaminase to generate -ketoglutarate (-KG), which directly enters the tricarboxylic acid (TCA) cycle [1]

Severely restricted caloric intake below 1,000 to 1,200 calories triggers metabolic adaptation that can stall weight loss

Rapid weight loss, as can occur with potent GLP-1 receptor agonists, may result in loss of both fat and lean tissue

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