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The largest study to date assessed the use of metformin 1 g, twice daily, in 428 people with type 1 diabetes who were treated for 3 years, with a primary endpoint of changes in mean carotid intimamedia thickness, a marker of cardiovascular disease risk

Yang R, et al

After 40, sleep architecture is already changing

Prog Neuropsychopharmacol Biol Psychiatry 20:11591170 Holmay MJ, Terpstra M, Coles LD, Mishra U, Ahlskog M, Oz G, Cloyd JC, Tuite PJ (2013) N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases

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