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In the brain, GLP-1 binding to its receptors can suppress appetite and reduce food intake, which may contribute to weight loss

That said, daily consistency is what drives colonization and sustained metabolite production

Importantly, there was heterogeneity between agents: liraglutide (3.0 mg weekly and 1.8 mg daily) achieved weight loss without significant lean mass reduction, whereas tirzepatide (15 mg weekly) and semaglutide (2.4 mg weekly) were least effective in preserving lean mass [22]

Minor, self-limiting effects include a small drop of blood at the site, brief stinging during injection, mild redness, and occasional light bruising

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