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Sustained UV exposure across most of the year, high indoor air-conditioning load that affects hydration, frequent intercontinental travel, demanding work schedules and a culture of high performance all generate sustained oxidative stress

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As pointed out [60], it has to be the counteraction of the reduced capillary perfusion pressure, increased cerebral blood volume, venous flow obstruction, increased intracranial pressure and blood-brain barrier disruption, resulting in a decreased cerebral blood flow [60]