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Reduced risk of heart failure with intensified multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: 21 years of follow-up in the randomised Steno-2 study

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Collectively, these data suggest that in the multistep metabolism of dietary l-carnitine into TMAO (i.e., l-carnitineBBTMATMAO), gut microbial metabolism of l-carnitineBB occurs rapidly in omnivore and vegan/vegetarian alike, and the latter microbial transformation of BB to TMA is the one markedly enhanced in omnivores over vegans/vegetarians (i.e., influenced by chronic dietary habits

In 1982, Holst and, separately, Dominique Bataille, a French endocrinologist based at INSERM in Montellier, France, together with Mutt isolated a smaller peptide from L-cells

The researchers then administered pTOS to obese and lean laboratory mice