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Excessive lipid metabolic reprogramming in OA significantly raises ferroptosis risk, so targeting lipid synthesis, transport, and degradation represents a promising upstream approach to reducing ferroptotic damage

For instance, avoiding sun exposure and wearing sunscreen with SPF 30 or higher daily are essential practices to prevent new pigmentation from forming

After gentle mixing, the protein solution was loaded to a S-Trap 96-well plate, spun at 1500 x g for 2 min, and the flow-through collected and reloaded onto the 96-well plate