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The increase in cAMP levels in -cells is a consequence of GLP-1R activation in these cells, which in turn enhances the secretion of growth inhibitory hormone through signaling pathways such as PKA and Calcium/Calmodulin-dependent protein kinase (Strowski et al., 2000

Molecules 29 (2), 317

Very recent findings also indicate that in the model of dextran sodium sulfate induced colitis, LTF protects gut integrity by increasing T regulatory cell population in intestinal lamina propria (112)

Clinically proven

(DOCX) Acknowledgments The authors thank Professor A David Smith for valuable discussions around the study, Ms Cheryl Turner for expert help with the mass spectrometry assays, and the staff at the Mary Lyon Centre for assistance with the animal work