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To explore gene expression changes, a multivariate reanalysis of the GSE1073233 dataset was performed, revealing major differences between untreated HepG2 and HepG2 ATP7B-KO cells, particularly in autophagy, lipid metabolism, and stress-related pathways

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The 2017 Squadrito review documents these effects across in vitro, in vivo, and clinical studies of PDRN in wound healing, with the salvage pathway and A2A receptor activation as the central mechanistic finding [18]

Liposomal Delivery for Enhanced Absorption