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In addition to changes in the microbiome composition, we investigated the effects of semaglutide and empagliflozin on the transformed abundances (z-scores) of predicted MetaCyc microbial pathways using PICRUSt2 (Methods)

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A phase 3 clinical study with a higher dosage of daily 25 and 50 mg of oral semaglutide is about to be initiated, in the hope of obtaining promising data for both body weight reduction and cardiovascular benefits [34,37]

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