Specifically, recent research has suggested a bidirectional communication between metabolic dysfunction (loss of metabolic homeostasis) and cellular senescence (67, 68)
The modulatory effects of GGT-mediated prooxidant reactions could contribute to the resistance phenotype of GGT-expressing cancer cells by regulating both signal transduction pathways involved in proliferation/apoptosis balance, as well as by inducing protective adaptations in the pool of intracellular antioxidants
These include dietary substances such as certain fatty acids and amino acids, vitamins, antioxidant plant substances including carotenoids and flavonoids, but also various types of spices [21]
This correlated with rescue of muscle weight/body weight ratios in older mice in locomotory (gastrocnemius, quadriceps, triceps) and respiratory (diaphragm) muscles
Mutations in the ETGE motif disrupt the high-affinity binding of Keap1 with Nrf2