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demonstrated that GIPR agonism could reduce the risk of atherosclerosis in sensitized animal models, and human genetics revealed a correlation between hypoglycemic alleles of GIPR and reduced BMI, triglyceride levels, and heart failure incidence [51]

But attributing that risk to semaglutide would be inaccurate

Results Changes in cholesterol content modulate exendin-4-induced GLP-1R behaviours in primary islets and in vivo To determine the effect of increased cholesterol levels on GLP-1R function, we fed mice a standard chow diet supplemented or not with cholesterol for 5 weeks

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Mercer et al., 2018