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PMID: 16822960

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Interestingly, when this reaction was studied in enzymes whose Fe(II) atoms are liganded by a cysteine residue, the cysteine ligand itself was left untouched by the nascent Fe(III)-OOH ( in vivo

FUN14 domain-containing protein 1 (FUNDC1), a mitophagy receptor highly expressed in the liver tissues of patients suffering from liver fibrotic injury as well as carbon tetrachloride-challenged mice, has been identified as a culprit in eliciting liver cell ferroptosis

Collectively, these data argue that HIF signaling should not be treated as a single protective or pathogenic pathway