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In this situation you can think of them as soldiers that help ward off the bad guys

Cellular Pathology (John Churchill, 1860)

To summarize, CAFs and ECM within the TME influence the HGF/c-MET signaling pathway through their interactions with immune cells and the secretion of HGF, leading to the formation of an immunosuppressive TME that accelerates tumor growth

doi: 10.1016/j.prnil.2016.05.002 142 BiesiadeckiMMooMBalawenderKKobyliskaZGaliniakS

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