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Comparison to Other Routes Intravenous: 100% bioavailability (by definitionthe full dose enters circulation) Subcutaneous: Likely 6090% bioavailability (depends on absorption rate) Oral: ~38% systemic bioavailability This is why some researchers hypothetically prefer injected routeshigher bioavailability means lower nominal doses are needed

He GN, Bao NR, Wang S, Xi M, Zhang TH, Chen FS

10.1006/geno.1997.4801

Mount Sinai, Vitamin B12 deficiency anemia, Niranjan N Singh, Florian P Thomas, Alan L Diamond at al, Vitamin B12-Associated Neurological Diseases, Medscape Mathew, A.R

The secret might just lie in a tripeptide known as glutathione