Our current study provides a detailed description of cellular and molecular crosstalk in the skin of eczema patients, proposing a mechanism supporting the development of allergen-induced inflammation
Most patients tolerate it well, which is part of why I am willing to discuss it more freely than peptides with more challenging side effect profiles
For example, PINK1 and Parkin loss of function impair mitophagy and cause accumulation of damaged mitochondria, leading to enhanced electron leakage and formation of superoxides 11,12,13
] Uribe PM, Kawas LH, Harding JW, Coffin AB
Finally, the dynamic crosstalk between microglia and other CNS cell types, including astrocytes, neurons, and endothelial cells, complicates the isolation of microglia-specific therapeutic effects