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For someone on the edge of prediabetes, that shift can meaningfully alter their long-term metabolic trajectory

There is already an appreciation within the medical literature that a narrow focus within outcomes trials misses the wider benefits of GLP-1 RAs across the CKM spectrum, and there are calls to review the design and analysis of outcomes trials in the CKM space to include more endpoints [44]

Discovery of novel hormetins is a necessary step, requiring an expansion of the search for hormetic substances beyond those already well-understood

F.BerdnikovsS.SimonH.-U.BochnerB

As such, the full impact of IcoSema on glycaemic management is greater than that illustrated by HbA 1c alone