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Smoking temporarily restores this balance, creating an immediate impression of relief

The lags selection was based on total cancer mortality, and we assume no difference in time delays between drinking and different cancer types

Patients and methods Patients cohort and evaluated clinical features Seventy-five patients, 44 index-cases and 31 relatives, with cEDS were evaluated from 2010 to 2019 in a tertiary referral center for the diagnosis and management of HCTDs (i.e., Ehlers-Danlos Syndrome and Inherited Connective Tissue Disorders Outpatient Clinic (CESED) at the Spedali Civili University Hospital of Brescia

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