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& Banerjee, R

Verdict: Limited evidence the absence of human trials reflects a combination of a cancelled unpublished safety study, specific FDA-documented safety concerns, and structural barriers that make large-scale human trials difficult to initiate and fund [4][10][1415]

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In a randomized placebo-controlled, double-blinded trial, although liraglutide did not affect A load and cognition measures, 26 weeks of liraglutide treatment prevented expected decline of glucose metabolism that signifies cognitive impairment, synaptic dysfunction, and disease evolution (243)