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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

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3,5 There are also some commonly prescribed medications that can deplete B12 levels

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Building the Stack: Step by Step Step 1 [1] : Pre-Stack Assessment Before starting the stack, complete the following: Physician consultation (telehealth or in-person) Baseline labs: metabolic panel, HbA1c, lipids, copper/ceruloplasmin (if any copper metabolism concern) Baseline photos: face, abdomen, arms, thighs, and any areas of concern, taken in consistent lighting Health history review: screen for semaglutide contraindications (thyroid cancer history, pancreatitis, MEN 2) and GHK-Cu contraindications (Wilson's disease, copper allergy) Getting started Step 2: Start Semaglutide Begin semaglutide at 0.25 mg once weekly