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While neuroinflammation occurs in ALS patients independent of the cause of the disease and thus should be a shared target, it is however likely that patients will respond differently to certain therapies depending on their progression rate and disease state when receiving the treatment

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In patients with syndromes like Laugier-Hunziker and Peutz-Jeghers mucosal melanosis can be diagnosed in high frequencies and in patients with inflammatory skin diseases like lichen planus genital melanosis have been reported (5,7-9)

16 The herbal supplements and weight-loss agents Hydroxycut and Herbalife have both been reported to cause acute liver failure, with patients presenting with either the hepatocellular or the cholestatic pattern of liver injury