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Arterial stiffness is characterized by structural (e.g., tunica media calcification, alterations in vascular smooth muscle cells, and fibrosis) and functional (e.g., loss of Windkessel function , elevated pulse pressure, and development of isolated systolic hypertension) vascular changes that cause microvascular dysfunction and end-organ damage (e.g., heart failure, vascular dementia, hypertensive retinopathy, and chronic kidney disease)

The review also concludes that although early studies are promising, most have involved small groups of patients, different study designs, and short follow-up periods

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These advancements could herald the beginning of a new era of obesity management, providing real hope for effective and accessible obesity treatment

Flores-Herr N, Protti DA, Wssle H