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In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl glycoside is dodecylmaltoside, tridecylmaltoside, and tetradecylmaltoside

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Similarly, in a mouse model of neuromyelitis optica spectrum disorder, Tregs accumulate around lesion sites and, more specifically, colocalize with inflammatory microglia and macrophages [160]

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