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Though the normal intestinal microbiome does not include large amounts of pathogenic organisms, as an example, increased proliferation of the pathogen Clostridium botulinum is associated with release of botulinum neurotoxins, damaging the intestinal barrier and fostering absorption of the neurotoxin into the systemic circulation and the nervous system, causing botulism [49]

Neurons are especially vulnerable to oxidative stress due to their high energy demands and limited regeneration capacity