Secondary BAs play a role in the modulation of immune system activity through BAs receptors, such as Takeda G-protein-coupled BAs receptor-1 (TGR5), farnesoid X receptor (FXR), pregnane X receptor (PXR), retinoid-related orphan receptor-t (RORyt), and Vitamin D receptor (VDR) [25]
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The company's FAQ also describes a clinical maximum of 8 doses per month for PT-141, which the company states is "established in FDA guidelines for the brand-name version (Vyleesi)." The dosing limitation exists because PT-141 can temporarily affect blood pressure
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