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These include enhancing intracellular TH availability via modulation of transporters such as monocarboxylate transporter 8 (MCT8) and deiodinases (e.g., DIO1), as well as directly targeting ECM remodeling through upregulation of MMP activity, inhibition of HA synthesis, and blockade of integrin-mediated signaling pathways (119121)

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We included costs of lost earnings due to absenteeism (acute and chronic), workforce dropout due to CVD or ESKD, and loss of future earnings from premature mortality (death before retirement age, which was set at 67 years)