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This design is useful for generating preliminary evidence from real clinical practice, but it has limitations compared to a randomised controlled trial (RCT)
Free Radic Res (2020) 54(1):126
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Use only the ring finger (least pressure), apply with gentle tapping or pressing along the orbital bone (never on the lid), use 1 drop per eye maximum, avoid direct contact with the eye, allow to absorb before applying any moisturizer, and never rub or drag the periocular skin
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