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Such a particular activity in angiogenesis and healing is concordant with the previous evidence that BPC 157 may directly protect endothelium (13), influence NO-system, counteract the effect of NOS-inhibitor and NO-precursor (14, 15), as well as over expression of endothelin (16)

Substantially contributed to analysis and manuscript preparation: Jiancheng Mou, Lichen Hong

Measured Precision: Uniform concentrations for reproducible outcomes of clinical studies

Of interest is the strict conservation of the four cysteines (Cys14, Cys47, Cys101 and Cys169) that confer peculiar redox sensitivity to this enzyme

Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: an in vitro and in vivo study in diabetic nephropathy mice model