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Abbreviations AE: adverse events ADA: American Diabetes Association CI: confidence interval CKD: chronic kidney disease CV: cardiovascular CVD: cardiovascular disease ETD: estimated treatment difference GLP-1RA: glucagon-like peptide-1 receptor agonist HR: hazard ratio MACE: major adverse cardiac event MI: myocardial infarction T2D: type 2 diabetes References American Diabetes Association

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A conceptual model of food cue reactivity, Nutrients (2023) Human drug compounding, Food and Drug Administration (2024) Compounding when drugs are on FDAs drug shortages list, Food and Drug Administration (2024) Your guide to FDA-approved medicines that contain semaglutide, Novo Nordisk FDA alerts health care providers, compounders, and patients of dosing errors associated with compounded injectable semaglutide products, Food and Drug Administration (2024) FDAs concerns with unapproved GLP-1 drugs used for weight loss, Food & Drug Administration (2024) Wegovy, DailyMed (2024) FDA warns patients and health care professionals not to use compounded drugs from Fullerton Wellness, Food and Drug Administration (2024) Novo Nordisk escalates legal actions to safeguard patients from potentially harmful compounded semaglutide drugs, Novo Nordisk (2024) FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize, Food and Drug Administration (2025) OFA v

A medically guided switching protocol is crucial for safely and effectively transitioning between weight loss medications