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If constipation persists beyond eight weeks or becomes severe, consultation with your healthcare provider is essential to rule out other causes and determine whether laxative use is appropriate for your specific situation

10.1158/0008-5472.CAN-21-0567 231 WangX.LiY.LiZ.LinS.WangH.SunJ.et al (2022)

However, brain glutathione levels may be relatively stable or regionally affected

Despite the exposure of mitochondria to the production of oxidants, the presence of an effective antioxidant system, of which mitochondrial GSH (mGSH) is a key component, prevents or repairs oxidative damage that occurs during normal aerobic metabolism [57]