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It is important to note that many of the studies that examined the efficacy of lipoic acid in the treatment of diabetic neuropathy have been primarily conducted by one German research group and funded by the manufacturer of lipoic acid in Germany (82)

AGEs may also promote vascular dysfunction by reducing the bioavailability of nitric oxide (NO) and inhibiting endothelial NO synthase and antioxidant defense mechanisms 13,14

No company currently has clear profit motive to spend millions funding human trials

Methods for measuring lipid oxidation

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