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Mechanistically, MBOAT1/2, which are lyso-PL acyltransferases (LPLATs), change monounsaturated fatty acids (MUFAs) into lyso-phosphatidylethanolamines (lyso-PEs), increasing the levels of PE-MUFAs and decreasing the levels of PE-PUFAs to suppress phospholipid peroxidation and inhibit ferroptosis [91]

Ectopic expression of SLC25A39 promotes LUAD malignant progression To investigate the functional role of SLC25A39 in LUAD cells, A549 and H1299 cells were transduced with a lentiviral vector encoding SLC25A39 (oeSLC25A39) or a control empty vector (Vec), followed by selection of stable cell lines using puromycin

It should be taken at least 30 minutes before a meal or at least 2 hours after a meal once per day