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Because GIPR activation is glucose-dependent, this entire cascade engages fully only when blood glucose exceeds approximately 5.6 mmol/L (100 mg/dL), which explains the low hypoglycemia rate observed in SURPASS trials even at the 15 mg dose [6]

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Studies consistently show that Ipamorelin maintains the natural pulsatile pattern of GH secretion rather than causing unnatural sustained elevation, which is considered beneficial for maintaining normal feedback regulation (PMID: 9849822)

In clinical trials, gastrointestinal adverse events were reported by a significant proportion of patients, though most were mild to moderate in severity and transient in nature