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Although CTLA-4 and PD-1 are part of separate pathways, they exert similar inhibitory effects on effector T cell metabolism, including downregulation of AKT phosphorylation, reduced amino acid uptake, and general suppression of metabolic activity

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(2013) Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation, Proc

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Isocitrate Dehydrogenase C