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A powerful and normally abundant antioxidant, glutathione protects cells from oxidative stress a condition that ensues when free radicals overwhelm the bodys ability to regulate them
It initiates a cascade of deleterious changes, including impaired energy metabolism, enhanced ROS production, and intracellular calcium overload
While the PP2A/AKT axis has not been examined in astrocytes, -arrestin-mediated recruitment of PP2A is a major mechanism by which D2-like receptors inhibit Akt (Beaulieu et al., 2005, 2015
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Liquiritin, a flavonoid glycoside of liquorice, has previously been shown to significantly reduce hyperpigmentation in 20 women with a clinical diagnosis of melasma
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