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Lithium remains the first-line therapy for manic-depressive illness, bipolar disorder 14 , traumatic brain injury 15 , and numerous neurodegenerative diseases, such as Alzheimers, Huntingtons, and Parkinsons diseases 16

The majority of folate entering tissue cells is in the form of 5-methyl-THF monoglutamate or is quickly metabolized to this form, which has a low affinity for folylpolyglutamate synthetase 894

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Glutathione is one of the bodys main antioxidants and plays a role in protecting cells from oxidative stress