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Neurological benefits including improved outcomes in demyelinating disease models point to CNS effects

11 / 13 12 / 13 You might lose your appetite, drop too much weight, or have trouble pooping (constipation)

NNMT inhibition increases cellular concentrations of both substrates that the enzyme would otherwise consume: SAM (the universal methyl donor) and nicotinamide (the NAD + salvage precursor)

Ideal candidates include individuals experiencing unexplained fatigue unresponsive to sleep and stress management, vegetarians and vegans lacking dietary B12 sources, adults over 50 with age-related absorption decline, patients with digestive disorders affecting nutrient absorption, those taking medications that deplete B12, and anyone seeking natural energy support without stimulants

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