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However, the rising prevalence of depression in the general population is coupled with an increasing number of patients who do not respond to antidepressant therapy, underlining the need to identify underlying factors to enable early detection and intervention, especially in high-risk groups [498]

I thought this blood work was done AFTER the initial loading doses of B12...so, yes, this result will be skewed

706 Metformin therapy activates the Nrf2 signaling pathway and improves SCI-induced motor dysfunction by inhibiting ferroptosis and the inflammatory response

While our body can make antioxidants, the modern environment (along with our bodies' natural cellular processes) makes it challenging to keep the balance of antioxidants and oxidative stress in check

The difference is that they often have access to expert care when those concerns come to a head