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People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE

It does this by activating the innate repair receptor (IRR), a heteromer of the EPO receptor and the beta-common receptor (CD131), which simultaneously triggers anti-inflammatory and tissue repair pathways

Is treated to remove any bacteria or contaminants, including minerals

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