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Centre for Perioperative Care

Mean change in bodyweight from baseline at week 40 was -69 kg with semaglutide 20 mg and -60 kg with semaglutide 10 mg (ETD -093 kg [95% CI -168 to -018]

It contains semaglutide, which helps regulate appetite and calorie intake

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (under the brand name Ozempic), chronic weight management in adults (as Wegovy), and weight management in pediatric patients aged 12 and older with obesity (also as Wegovy)

Bupropion typically does not affect menstrual cycles directly, but the stress of managing overlapping side effects and the physiological demands of concurrent weight loss and psychiatric medication can contribute to cycle irregularity