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Using CY 2024 claims data, CPT code 47555 had geometric mean cost of $8,577.51 in the CY 2026 OPPS/ASC proposed rule

Side effects, safety, and the boxed warning All GLP-1 agonists (and tirzepatide, a GIP/GLP-1 dual agonist) share a well-characterized profile: nausea, vomiting, diarrhea, constipation, abdominal pain, and headache are common, especially during the first 48 weeks and after each dose escalation

For example, Meissner et al133 conducted a randomized controlled trial evaluating lixisenatide in patients with early stage PD receiving standard treatment

There is also a benign side effect of a fishy odor, which may occur during supplementation

However, GLP-1 agonists are unlikely to protect beta cells in type 1 diabetes, even though their other effects can be quite helpful