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In vivo , obesity and insulin resistance in mice were associated with GPx-1 overexpression, further supporting a dual role for GPx-1 in regulating different types of oxidative stress with a possible deleterious impact on metabolism, molecular, and physiological functions

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Pilichiewicz AN, Chaikomin R, Brennan IM, Wishart JM, Rayner CK, Jones KL et al

In the ESSENCE trial, patients with T2D showed HbA1c reduction of 1.08% with semaglutide versus 0.0% with placebo, while those without T2D showed a reduction of 0.42% versus +0.11% with placebo

The QV formulation also had a positive effect on the lipid profile of diabetic rats, reducing non-HDL fraction and increasing HDL fraction, which is of particular significance because lipidic metabolism is directly related to dyslipidemia as well as microvascular and cardiovascular complications are typical of diabetes 30