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Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE

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Most of the early studies focused on its effects on the stomach and intestines

The success of tirzepatide has validated the multi-agonist approach, driving substantial research and development in this area

Notably, miR-4443 has been implicated in tumorigenesis, metastasis, and chemotherapy resistance, underscoring its dual role in cancer progression [103]